Post Doctoral position available
Functional Optical Image Processing/Visualisation of the Human Brain
March 2013-March 2014
Place: Inserm U 1105
GRAMFC, Research Group on Multimodal Analysis of Brain Function
Université de Picardie Jules Verne, Centre Hospitalier Universitaire d’Amiens, 3 rue des Louvels, 80036 Amiens http://www.u-picardie.fr/labo/UGBM/
Head of the Unit : Pr Fabrice Wallois
Funding: Inserm
Subject:
Functional Optical Imaging (fOI) of the brain by near infrared spectroscopy is an upcoming technique to evaluate the human brain functions and dysfunctions. As for fMRi It is based on local hemodynamic changes associated with cortical brain activation due to external (auditory….) or internal (epilepsy….) stimuli. Such tool can be used simultaneously to electroencephalography and is known as EEG/fNIRS recordings. Because both share similar time and space resolution, they provide complementary information about the functioning/dysfunctioning brain. This combined approach can be used in prematures as in adults. Because it can be performed at bedside, in prematures fOI allows to evaluate the functional dynamic of the brain maturation at the earliest stage of the development. Because it does not required to be performed in a restricted area, in adlults, fOI is used whenever fMRI is not feasible. fOI has already provided interesting information concerning brain function. Early studies started with basic paradigms, activating the sensorimotor areas and intended to show the capability of the fOI technique for monitoring localized regions of the cortex (Maki, 1995; Takahashi, 2000).
More recently, in our laboratory we performed studies to look at the development of cognitive processing and assessment in prematures (Mahmoudzadeh, 2013) and at the impact on the brain of epileptic activities in patients suffering from epilepsy. We could found in prematures that as early as three months prior to term, the immature human brain has established specific neural functions that key on and help decipher human speech. In epilepsy, using fOI, we could describe epileptogenic areas which were not observed by electroencephalography. Multimodal (fOI, EEG, fMRI, PET Scann) analysis in epilepsy is under process in the framework of a national grant.
The Inserm Group (Inserm U 1105) wish to develop tools of Image Processing/Visualisation of the Human Brain using functional optical imaging by High Density Near Infrared Spectroscopy and Electrical Source Imaging by High Resolution ElectrEncephaloGraphy .
This will be performed to visualize in one side, in premature, in 4D, the maturation of the language network (Mahmoudzadeh et al., PNAS 2013) and in the other side, in children, the neuronal networks involved in refractory epilepsy as a guidance for presurgical evaluation and implantation of intracerebral electrodes.
For this purpose we sought a highly motivated candidate for a post doc position of 12 months (possibility to be extended to 24 months) This candidate should have a PhD in graphic informatics with an important experience in 3D image processing Interactions with colleagues will be determinant since data to be treated rely on signal processing performed by engineers in signal treatment and interactions with physiologists and clinicians. A PhD student has also already be recruited for fOI signal treatment.
Personal autonomy with image processing tools is compulsory for the position. Experience in Brain imaging is a plus but is not obligatory.
The candidate shall send his CV and reference letters to: Fabrice Wallois, GRAMFC, EFSN Pédiatrique, CHU Amiens Nord, Place V. Pauchet 80054 Amiens Cedex, France. Email fabrice.wallois@u-picardie.fr, tel + 33 6 83 12 07 14.
The position is available now and the brut Salary is 2514.25€ per month.
Mahmoudzadeh, M., Dehaene-Lambertz, G., Fournier, M., Kongolo, G., Goudjil, S., Dubois, J., Grebe, R., Wallois, F., Syllabic discrimination in premature human infants prior to complete formation of cortical layers, PNAS, 2013 In press (IF=10.5)
Application Deadline : 30 April 2013
Contact Adress: Fabrice Wallois, GRAMFC, EFSN Pédiatrique, CHU Amiens Nord, Place V. Pauchet 80054 Amiens Cedex, France
Contact Email: fabrice.wallois@u-picardie.fr,
Posted on 2013-04-05 01:53:30
France : PhD position in neuroscience
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